Objectives:
Chronic renal failure is a permanent decrease in the glomerular filtration rate with increasing deterioration of renal function. Decreased insulin sensitivity, insufficient release of insulin and increased hepatic gluconeogenesis contribute to insulin resistance in chronic renal failure.
Methods:
Ninety-seven patients (age range: 20-70, hemodialysis applied in 51 and peritoneal dialysis in 46), who were under follow-up and treatment at the Ministry of Health Istanbul Training and Research Hospital, Internal Medicine and Nephrology outpatient clinics, were included in our study. The patients were divided into two groups as the hemodialysis group (n: 51) and peritoneal dialysis group (n: 46), and their insulin resistance was compared with the Homeostasis Model Assessment (HOMA).
Results:
The mean HOMA in the peritoneal dialysis group (2.59±1.69) was statistically significantly higher than in the hemodialysis group (1.91±1.47) (p=0.036).
Conclusion:
Even though peritoneal dialysis removes medium-molecular-weight toxins better in dialysis patients compared to hemodialysis treatment, it affects insulin sensitivity unfavorably due to the hyperglycemia and hyperlipidemia burden caused by the glucose present in the dialysis solution.
Keywords: Dialysis, insulin resistance, chronic renal failure